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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cytochrome c oxidase subunit 2

UniprotKB/SwissProt ID: COX2_MOUSE (P00405)

Gene Name: Mtco2

Synonyms: COII, mt-Co2

Organism: Mus musculus (Mouse).

Function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.

Network with metabolic pathway:
Kegg map ID Pathway Link
map00190Oxidative phosphorylation
map04260Cardiac muscle contraction
map05010Alzheimer's disease
map05012Parkinson's disease
map05016Huntington's disease
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001505
IPR002429
IPR008972
IPR011759
IPR014222
IPR015964

The S-nitrosylation sites of COX2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1117SYEYTDYEDL C FDSYMIPTND EEEECCCCCC C CCCCCCCCCC 5.72%MC1322865876in vivo
2196SNRPGLFYGQ C SEICGSNHSF EECCEEEEEE E CCCCCCCCCC 3.24%MC1322865876in vivo
3200GLFYGQCSEI C GSNHSFMPIV EEEEEEECCC C CCCCCCCEEE 4.25%MC0722865876in vivo