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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cytochrome P450 2C8

UniprotKB/SwissProt ID: CP2C8_HUMAN (P10632)

Gene Name: CYP2C8

Organism: Homo sapiens (Human).

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
OMIM601129CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 8; CYP2C8 RHABDOMYOLYSIS, CERIVASTATIN-INDUCED,
HPRD03083Rhabdomyolysis, cerivastatin-induced
Network with metabolic pathway:
Kegg map ID Pathway Link
map00590Arachidonic acid metabolism
map00591Linoleic acid metabolism
map00830Retinol metabolism
map00980Metabolism of xenobiotics by cytochrome P450
map00982Drug metabolism - cytochrome P450
map04726Serotonergic synapse
map05204Chemical carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001128
IPR002401

The S-nitrosylation sites of CP2C8_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1435FMPFSAGKRI C AGEGLARMEL EECCCCCCCC C HHHHHHHHHH 4.64%HC0924105792
(Cys434)
-