Protein Name: Cytochrome P450 2C8
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UniprotKB/SwissProt ID: CP2C8_HUMAN (P10632)
Gene Name: CYP2C8
Organism: Homo sapiens (Human).
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
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Protein disease:
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Disease database |
Database Entry |
Disease information | OMIM | 601129 | CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 8; CYP2C8 RHABDOMYOLYSIS, CERIVASTATIN-INDUCED, | HPRD | 03083 | Rhabdomyolysis, cerivastatin-induced |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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