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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cytochrome P450 2F2

UniprotKB/SwissProt ID: CP2F2_MOUSE (P33267)

Gene Name: Cyp2f2

Synonyms: Cyp2f-2

Organism: Mus musculus (Mouse).

Function: Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl- 1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Network with metabolic pathway:
Kegg map ID Pathway Link
map00980Metabolism of xenobiotics by cytochrome P450
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001128
IPR002401
IPR008067

The S-nitrosylation sites of CP2F2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1267DPNSPRDFID C FLTKMAQEKQ CCCCCHHHHH H HHHHHHHCCC 2.29%MC0322178444-
2267DPNSPRDFID C FLTKMAQEKQ CCCCCHHHHH H HHHHHHHCCC 2.29%MC0320837516in vivo
3436FMPFSAGRRL C LGEPLARMEL EECCCCCCCC C HHHHHHHHHH 4.32%MC0522178444-
4436FMPFSAGRRL C LGEPLARMEL EECCCCCCCC C HHHHHHHHHH 4.32%MC0520837516in vivo
5487LGNLPRPFQL C MHIR------ CCCCCCCCEE E EEEC 0.98%MC0622178444-
6487LGNLPRPFQL C MHIR------ CCCCCCCCEE E EEEC 0.98%MC0620837516in vivo