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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cleavage and polyadenylation specificity factor subunit 6

UniprotKB/SwissProt ID: CPSF6_HUMAN (Q16630)

Gene Name: CPSF6

Synonyms: CFIM68

Organism: Homo sapiens (Human).

Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.

PDB :
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Network with metabolic pathway:
Kegg map ID Pathway Link
map03015mRNA surveillance pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000504
IPR012677