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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cleavage and polyadenylation specificity factor subunit 6

UniprotKB/SwissProt ID: CPSF6_MOUSE (Q6NVF9)

Gene Name: Cpsf6

Organism: Mus musculus (Mouse).

Function: Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (By similarity). Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map03015mRNA surveillance pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000504
IPR012677

The S-nitrosylation sites of CPSF6_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1159LHGQSPVVTP C NKQFLSQFEM CCCCCCCCCC C CCCCCCCCCC 7.89%MC0621278135in vitro