Protein Name: Colorectal mutant cancer protein
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UniprotKB/SwissProt ID: CRCM_HUMAN (P23508)
Gene Name: MCC
Organism: Homo sapiens (Human).
Function: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 159350 | MUTATED IN COLORECTAL CANCERS; MCC | | HPRD | 01157 | Colorectal cancer |
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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