UniprotKB/SwissProt ID: CSRP3_MOUSE (P50462)
Gene Name: Csrp3
Synonyms: Clp, Mlp
Organism: Mus musculus (Mouse).
Function: Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus (Potential). Cytoplasm. Cytoplasm, cytoskeleton (Potential). Cytoplasm, myofibril, sarcomere, Z line. Note=Mainly cytoplasmic. In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3 (via C
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