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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Catenin beta-1

UniprotKB/SwissProt ID: CTNB1_HUMAN (P35222)

Gene Name: CTNNB1

Synonyms: CTNNB

Organism: Homo sapiens (Human).

Function: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalized with RAPGEF2 and TJP1

PDB :
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Protein disease:
Disease database Database Entry Disease information
KEGGH00018 Gastric cancer
KEGGH00020 Colorectal cancer
KEGGH00026 Endometrial Cancer
KEGGH00032 Thyroid cancer
KEGGH00048 Hepatocellular carcinoma
KEGGH00947 Pilomatricoma; Epithelioma calcificans of Malherbe
OMIM114500COLORECTAL CANCER; CRC ;;COLON CANCER
OMIM114550HEPATOCELLULAR CARCINOMA ;;HCC;; CANCER, HEPATOCELLULAR;; LIVER CANCER;; LIVER CELL CARCINOM
OMIM116806CATENIN, BETA-1; CTNNB1 ;;CADHERIN-ASSOCIATED PROTEIN, BETA; CTNNB
OMIM132600PILOMATRIXOMA ;;PILOMATRICOMA; PTR;; EPITHELIOMA CALCIFICANS OF MALHERBE
OMIM615075MENTAL RETARDATION, AUTOSOMAL DOMINANT 19; MRD19
HPRD00286Colorectal cancer
HPRD00286Hepatoblastoma, somatic
HPRD00286Hepatocellular carcinoma, somatic
HPRD00286Ovarian carcinoma, endometrioid type, somatic
HPRD00286Pilomatricoma, somatic
Network with metabolic pathway:
Kegg map ID Pathway Link
map05130Pathogenic Escherichia coli infection
map05213Endometrial cancer
map05216Thyroid cancer
map05217Basal cell carcinoma
map05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
map04520Adherens junction
map04670Leukocyte transendothelial migration
map05100Bacterial invasion of epithelial cells
map05210Colorectal cancer
map05215Prostate cancer
map04310Wnt signaling pathway
map04510Focal adhesion
map04530Tight junction
map04916Melanogenesis
map05166HTLV-I infection
map05200Pathways in cancer
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000225
IPR000357
IPR011989
IPR013284

The S-nitrosylation sites of CTNB1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1520TVGLIRNLAL C PANHAPLREQ HHHHHHHHHC C CHHHHHHHHC 2.19%HC1224105792-