Protein Name: Catenin beta-1
|
UniprotKB/SwissProt ID: CTNB1_HUMAN (P35222)
Gene Name: CTNNB1
Synonyms: CTNNB
Organism: Homo sapiens (Human).
Function: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalized with RAPGEF2 and TJP1
| PDB : ( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. ) |
|
Protein disease:
|
Disease database |
Database Entry |
Disease information | KEGG | H00018 | Gastric cancer | KEGG | H00020 | Colorectal cancer | KEGG | H00026 | Endometrial Cancer | KEGG | H00032 | Thyroid cancer | KEGG | H00048 | Hepatocellular carcinoma | KEGG | H00947 | Pilomatricoma; Epithelioma calcificans of Malherbe | OMIM | 114500 | COLORECTAL CANCER; CRC ;;COLON CANCER | OMIM | 114550 | HEPATOCELLULAR CARCINOMA ;;HCC;; CANCER, HEPATOCELLULAR;; LIVER CANCER;; LIVER CELL CARCINOM | OMIM | 116806 | CATENIN, BETA-1; CTNNB1 ;;CADHERIN-ASSOCIATED PROTEIN, BETA; CTNNB | OMIM | 132600 | PILOMATRIXOMA ;;PILOMATRICOMA; PTR;; EPITHELIOMA CALCIFICANS OF MALHERBE | OMIM | 615075 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 19; MRD19 | HPRD | 00286 | Colorectal cancer | HPRD | 00286 | Hepatoblastoma, somatic | HPRD | 00286 | Hepatocellular carcinoma, somatic | HPRD | 00286 | Ovarian carcinoma, endometrioid type, somatic | HPRD | 00286 | Pilomatricoma, somatic |
|
Network with metabolic pathway:
|
|
Graphical Visualization of S-nitrosylation Sites:
|
Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
|