logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Catenin beta-1

UniprotKB/SwissProt ID: CTNB1_MOUSE (Q02248)

Gene Name: Ctnnb1

Synonyms: Catnb

Organism: Mus musculus (Mouse).

Function: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, adherens junction. Cell membrane (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Cytoplasm, cytoskeleton, spindle pole (By similarity). Note=

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map05213Endometrial cancer
map05216Thyroid cancer
map05217Basal cell carcinoma
map05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
map04520Adherens junction
map04670Leukocyte transendothelial migration
map05100Bacterial invasion of epithelial cells
map05210Colorectal cancer
map05215Prostate cancer
map04310Wnt signaling pathway
map04510Focal adhesion
map04530Tight junction
map04916Melanogenesis
map05166HTLV-I infection
map05200Pathways in cancer
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000225
IPR000357
IPR011989
IPR013284

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1DOW X-ray 1.80 A B118-149Link
1I7W X-ray 2.00 A A/C134-671Link
1I7X X-ray 3.00 A A/C134-671Link
1JPP X-ray 3.10 A A/B134-671Link
1M1E X-ray 2.10 A A134-671Link
1V18 X-ray 2.10 A A134-671Link
2BCT X-ray 2.90 A A150-665Link
3BCT X-ray 2.10 A A193-662Link
3OUW X-ray 2.91 A A134-671Link
3OUX X-ray 2.40 A A134-671Link
4EV8 X-ray 1.90 A A134-671Link
4EV9 X-ray 2.10 A A134-671Link
4EVA X-ray 2.00 A A/C134-671Link
4EVP X-ray 2.26 A A134-671Link
4EVT X-ray 2.34 A A134-671Link

The S-nitrosylation sites of CTNB1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1213QNTNDVETAR C TAGTLHNLSH HHCCHHHHHH H HHHHHHHHHC 2.58%MC0220925432in vivo