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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Catenin delta-1

UniprotKB/SwissProt ID: CTND1_HUMAN (O60716)

Gene Name: CTNND1

Synonyms: KIAA0384

Organism: Homo sapiens (Human).

Function: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. Isoforms 4A and 1AB are excl

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
OMIM601045CATENIN, DELTA-1; CTNND1 ;;CATENIN, DELTA; CTNND;; CADHERIN-ASSOCIATED SRC SUBSTRATE; CAS;;
Network with metabolic pathway:
Kegg map ID Pathway Link
map04520Adherens junction
map04670Leukocyte transendothelial migration
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000225
IPR011989

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3L6X X-ray 2.40 A A324-937Link
3L6Y X-ray 3.00 A A/C/E324-937Link

The S-nitrosylation sites of CTND1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1394SNAAAYLQHL C YRNDKVKTDV HHHHHHHHHH H HHHHHHHHHH 2.55%HC0919483679in vivo