Protein Name: Catenin delta-1
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UniprotKB/SwissProt ID: CTND1_HUMAN (O60716)
Gene Name: CTNND1
Synonyms: KIAA0384
Organism: Homo sapiens (Human).
Function: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. Isoforms 4A and 1AB are excl
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Protein disease:
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Disease database |
Database Entry |
Disease information | OMIM | 601045 | CATENIN, DELTA-1; CTNND1 ;;CATENIN, DELTA; CTNND;; CADHERIN-ASSOCIATED SRC SUBSTRATE; CAS;; |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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