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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Catenin delta-1

UniprotKB/SwissProt ID: CTND1_MOUSE (P30999)

Gene Name: Ctnnd1

Synonyms: Catns, Kiaa0384

Organism: Mus musculus (Mouse).

Function: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation. Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map04520Adherens junction
map04670Leukocyte transendothelial migration
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000225
IPR011989

The S-nitrosylation sites of CTND1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1394SNAAAYLQHL C YRNDKVKTDV HHHHHHHHHH H HHHHHHHHHH 2.55%MC0420925432in vivo
2429HPKKEVHLGA C GALKNISFGR CCCHHHHHHH H HHHHHHHCCC 2.88%MC0120925432in vivo
3450DQDNKIAIKN C DGVPALVRLL CHHHHHHHHH C CCHHHHHHHH 4.01%MC0921278135in vitro
4533WESVLTNTAG C LRNVSSERSE HHHHHHHHHH H HHHHHHCCHH 2.75%MC0620925432in vivo