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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cruzipain

UniprotKB/SwissProt ID: CYSP_TRYCR (P25779)

Gene Name:

Organism: Trypanosoma cruzi.

Function: Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000169
IPR000668
IPR013128
IPR013201

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1AIM X-ray 2.00 A A123-337Link
1EWL X-ray 2.00 A A123-337Link
1EWM X-ray 2.00 A A123-337Link
1EWO X-ray 2.10 A A123-337Link
1EWP X-ray 1.75 A A123-337Link
1F29 X-ray 2.15 A A/B/C123-337Link
1F2A X-ray 1.60 A A123-337Link
1F2B X-ray 1.80 A A123-337Link
1F2C X-ray 2.00 A A123-337Link
1ME3 X-ray 1.20 A A123-337Link
1ME4 X-ray 1.20 A A123-337Link
1U9Q X-ray 2.30 A X123-337Link
2AIM X-ray 2.20 A A123-337Link
2OZ2 X-ray 1.95 A A/C123-337Link
3HD3 X-ray 1.75 A A/B123-337Link
3I06 X-ray 1.10 A A123-337Link
3IUT X-ray 1.20 A A123-337Link
3KKU X-ray 1.28 A A123-337Link
3LXS X-ray 1.50 A A/C123-337Link
4KLB X-ray 2.62 A A/B/C/D/E123-337Link

The S-nitrosylation sites of CYSP_TRYCR

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1147AVKDQGQCGS C WAFSAIGNVE CCCCCCCCCC H HHHHHHHHHH 1.52%N/A22178444-
2147AVKDQGQCGS C WAFSAIGNVE CCCCCCCCCC H HHHHHHHHHH 1.52%N/A10753643
(Cys25)
in vitro