logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

UniprotKB/SwissProt ID: DDAH1_HUMAN (O94760)

Gene Name: DDAH1

Synonyms: DDAH

Organism: Homo sapiens (Human).

Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR003198

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2JAI X-ray 2.30 A A/B2-284Link
2JAJ X-ray 2.00 A A/B2-284Link
3I2E X-ray 2.03 A A/B1-285Link
3I4A X-ray 1.90 A A/B1-285Link
3P8E X-ray 2.49 A A/B1-285Link
3P8P X-ray 2.50 A A/B1-285Link

The S-nitrosylation sites of DDAH1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1222LTVPDDIAAN C IYLNIPNKGH CCCCCCCCCC E EECCCCCCCC 1.53%HC1222178444-
2222LTVPDDIAAN C IYLNIPNKGH CCCCCCCCCC E EECCCCCCCC 1.53%HC1212441345-
3274ELEKVDGLLT C CSVLINKKVD HHHHCCCCCE E EEEECCCCCC 1.32%HC0122178444-
4274ELEKVDGLLT C CSVLINKKVD HHHHCCCCCE E EEEECCCCCC 1.32%HC0112441345-