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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Desmoplakin

UniprotKB/SwissProt ID: DESP_HUMAN (P15924)

Gene Name: DSP

Organism: Homo sapiens (Human).

Function: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell junction, desmosome. Cytoplasm, cytoskeleton. Note=Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network.

PDB :
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Protein disease:
Disease database Database Entry Disease information
HPRD00513Arrhythmogenic right ventricular dysplasia, familial, 8
HPRD00513Dilated cardiomyopathy with woolly hair and keratoderma
HPRD00513Epidermolysis bullosa, lethal acantholytic
HPRD00513Keratosis palmoplantaris striata II
HPRD00513Skin fragility-woolly hair syndrome
Network with metabolic pathway:
Kegg map ID Pathway Link
map05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001101
IPR002017