Protein Name: Desmoplakin
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UniprotKB/SwissProt ID: DESP_HUMAN (P15924)
Gene Name: DSP
Organism: Homo sapiens (Human).
Function: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell junction, desmosome. Cytoplasm, cytoskeleton. Note=Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network.
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Protein disease:
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Disease database |
Database Entry |
Disease information | HPRD | 00513 | Arrhythmogenic right ventricular dysplasia, familial, 8 | HPRD | 00513 | Dilated cardiomyopathy with woolly hair and keratoderma | HPRD | 00513 | Epidermolysis bullosa, lethal acantholytic | HPRD | 00513 | Keratosis palmoplantaris striata II | HPRD | 00513 | Skin fragility-woolly hair syndrome |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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