Protein Name: Estradiol 17-beta-dehydrogenase 12
|
UniprotKB/SwissProt ID: DHB12_HUMAN (Q53GQ0)
Gene Name: HSD17B12
Organism: Homo sapiens (Human).
Function: Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
| |
|
Protein disease:
|
Disease database |
Database Entry |
Disease information | OMIM | 609574 | 17-@BETA-HYDROXYSTEROID DEHYDROGENASE XII; HSD17B12 ;;17-@BETA-HSD XII;; 3-@KETOACYL-CoA RED |
|
Network with metabolic pathway:
|
|
Graphical Visualization of S-nitrosylation Sites:
|
Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
|