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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Estradiol 17-beta-dehydrogenase 12

UniprotKB/SwissProt ID: DHB12_HUMAN (Q53GQ0)

Gene Name: HSD17B12

Organism: Homo sapiens (Human).

Function: Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein disease:
Disease database Database Entry Disease information
OMIM60957417-@BETA-HYDROXYSTEROID DEHYDROGENASE XII; HSD17B12 ;;17-@BETA-HSD XII;; 3-@KETOACYL-CoA RED
Network with metabolic pathway:
Kegg map ID Pathway Link
map00062Fatty acid elongation
map00140Steroid hormone biosynthesis
map01040Biosynthesis of unsaturated fatty acids
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002198
IPR002347