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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Estradiol 17 beta-dehydrogenase 5

UniprotKB/SwissProt ID: DHB5_MOUSE (P70694)

Gene Name: Akr1c6

Synonyms: Hsd17b5

Organism: Mus musculus (Mouse).

Function: Active toward androgens, estrogens, and xenobiotic substrates. Also exhibits low 20 alpha-HSD activity. Shows a- stereospecificity in hydrogen transfer between cofactors and substrates (A-specific). Preferentially catalyzes the reduction of 4-androstenedione, 5-alpha-androstane-3,17-dione, androsterone and dehydroepiandrosterone to testosterone, dihydrotestosterone, 5- alpha-androstane-3-alpha,17-beta-diol and 5-androstene-3-beta,17- beta-diol, respectively.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Network with metabolic pathway:
Kegg map ID Pathway Link
map00051Fructose and mannose metabolism
map00591Linoleic acid metabolism
map00650Butanoate metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001395
The S-nitrosylation sites of DHB5_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
198TFHRPELVRV C LEQSLKQLQL CCCCHHHHHH H HHHHHHHCCC 2.13%MC0122178444-
298TFHRPELVRV C LEQSLKQLQL CCCCHHHHHH H HHHHHHHCCC 2.13%MC0120837516in vivo
3188KKPGLKYKPV C NQVECHPYLN HCCCCCCCCE E EEEECCCCCC 3.90%MC0222178444-
4188KKPGLKYKPV C NQVECHPYLN HCCCCCCCCE E EEEECCCCCC 3.90%MC0220837516in vivo
5193KYKPVCNQVE C HPYLNQGKLL CCCCEEEEEE C CCCCCCHHHH 4.04%MC1322178444-
6193KYKPVCNQVE C HPYLNQGKLL CCCCEEEEEE C CCCCCCHHHH 4.04%MC1320837516in vivo
7206YLNQGKLLDF C RSKDIVLVAY CCCCHHHHHH H HHCCCEEEEE 4.85%MC1222178444-
8206YLNQGKLLDF C RSKDIVLVAY CCCCHHHHHH H HHCCCEEEEE 4.85%MC1220837516in vivo