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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Estradiol 17-beta-dehydrogenase 8

UniprotKB/SwissProt ID: DHB8_MOUSE (P50171)

Gene Name: Hsd17b8

Synonyms: H2-Ke6, Hke6

Organism: Mus musculus (Mouse).

Function: NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (By similarity). The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00140Steroid hormone biosynthesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002198
IPR002347

The S-nitrosylation sites of DHB8_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
139LAAEGAAVAA C DLDGAAAQDT HHHHCCCEEE E EECCHHHHHH 3.73%MC1321278135in vitro
2192ARELGRHGIR C NSVLPGFIAT HHHHHHHCCC E EEEECCCCCC 4.15%MC0821278135in vitro