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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Sorbitol dehydrogenase

UniprotKB/SwissProt ID: DHSO_MOUSE (Q64442)

Gene Name: Sord

Synonyms: Sdh1

Organism: Mus musculus (Mouse).

Function: Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion membrane; Peripheral membrane protein. Cell projection, cilium, flagellum. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by

Network with metabolic pathway:
Kegg map ID Pathway Link
map00051Fructose and mannose metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002085
IPR002328
IPR011032
IPR011597
IPR013149
IPR013154

The S-nitrosylation sites of DHSO_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1179SVSLGNKVLV C GAGPVGMVTL HHHHHHHHHH H HHHHHHCCCC 2.43%MC1022178444-
2179SVSLGNKVLV C GAGPVGMVTL HHHHHHHHHH H HHHHHHCCCC 2.43%MC1020837516in vivo
3350KGVGLKVMIK C DPNDQNP--- EEEECCHHHH H HHHHHHHCCC 7.91%MC1322178444-
4350KGVGLKVMIK C DPNDQNP--- EEEECCHHHH H HHHHHHHCCC 7.91%MC1320837516in vivo