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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15

UniprotKB/SwissProt ID: DHX15_MOUSE (O35286)

Gene Name: Dhx15

Synonyms: Ddx15, Deah9

Organism: Mus musculus (Mouse).

Function: Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Nucleus, nucleolus (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map03040Spliceosome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001650
IPR002464
IPR003593
IPR007502
IPR011709
IPR014001
IPR014021

The S-nitrosylation sites of DHX15_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1190SLPGPKRGVA C TQPRRVAAMS CCCCCCCCEE E ECCCHHHHHH 3.18%MC0421278135in vitro
2226EVGYSIRFED C SSAKTILKYM CCCEEECCCC C CCCCCEEEEE 2.45%MC0720925432in vivo