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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dystrophin

UniprotKB/SwissProt ID: DMD_MOUSE (P11531)

Gene Name: Dmd

Organism: Mus musculus (Mouse).

Function: Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin- associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane. Note=In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to cost

Network with metabolic pathway:
Kegg map ID Pathway Link
map05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
map05410Hypertrophic cardiomyopathy (HCM)
map05414Dilated cardiomyopathy
map05416Viral myocarditis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000433
IPR001202
IPR001589
IPR001715
IPR002017
IPR011992
IPR015153
IPR015154

The S-nitrosylation sites of DMD_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
11507QEVIQSQLSH C VNLYKSLSEV HHHHHHHHHH H HHHHHHHHHH 1.63%MC0422865876in vivo