UniprotKB/SwissProt ID: DNJC7_HUMAN (Q99615)
Gene Name: DNAJC7
Synonyms: TPR2, TTC2
Organism: Homo sapiens (Human).
Function: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone- substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=Colocalizes with NR1I3 to microtubules (By similarity).
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