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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dynamin-1-like protein

UniprotKB/SwissProt ID: DNM1L_HUMAN (O00429)

Gene Name: DNM1L

Synonyms: DLP1, DRP1

Organism: Homo sapiens (Human).

Function: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis- dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Golgi apparatus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome. Membrane, clathrin-coated pit (By similarity). Cytoplasmic vesicle, secretory vesicle, synaptic

Protein disease:
Disease database Database Entry Disease information
OMIM603850DYNAMIN 1-LIKE; DNM1L ;;DYNAMIN-LIKE PROTEIN 1; DLP1;; DYNAMIN-RELATED PROTEIN 1; DRP1;; S.
OMIM614388ENCEPHALOPATHY, LETHAL, DUE TO DEFECTIVE MITOCHONDRIAL AND PEROXISOMAL FISSION; EMPF
Network with metabolic pathway:
Kegg map ID Pathway Link
map04721Synaptic vesicle cycle
map04961Endocrine and other factor-regulated calcium reabsorption
map04666Fc gamma R-mediated phagocytosis
map05100Bacterial invasion of epithelial cells
map04144Endocytosis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000375
IPR001401
IPR003130

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3W6N X-ray 2.00 A A/B1-329Link
3W6O X-ray 1.90 A A/B1-329Link
A/B709-736
3W6P X-ray 1.70 A A/B1-329Link
4BEJ X-ray 3.48 A A/B/C/D1-736Link
4H1U X-ray 2.30 A A711-736Link
4H1V X-ray 2.30 A A2-327Link

The S-nitrosylation sites of DNM1L_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1367TSELCGGARI C YIFHETFGRT CCCCCCHHHH H HHHHHHHHHH 1.45%HC0922178444-
2367TSELCGGARI C YIFHETFGRT CCCCCCHHHH H HHHHHHHHHH 1.45%HC0919101475-
3644RKLSAREQRD C EVIERLIKSY CCCCHHHHHH H HHHHHHHHHH 4.98%HC0322178444-
4644RKLSAREQRD C EVIERLIKSY CCCCHHHHHH H HHHHHHHHHH 4.98%HC0319342591-
5644RKLSAREQRD C EVIERLIKSY CCCCHHHHHH H HHHHHHHHHH 4.98%HC0319417214-