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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dihydropyrimidinase-related protein 2

UniprotKB/SwissProt ID: DPYL2_HUMAN (Q16555)

Gene Name: DPYSL2

Synonyms: CRMP2, ULIP2

Organism: Homo sapiens (Human).

Function: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane. Note=Tightly but non-covalently associated with membranes.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04360Axon guidance
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR005847
IPR006680
IPR011059
IPR011778

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2GSE X-ray 2.40 A A/B/C/D13-490Link
2VM8 X-ray 1.90 A A/B/C/D13-490Link

The S-nitrosylation sites of DPYL2_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1504VPRGLYDGPV C EVSVTPKTVT CCCCCCCCCC C CCCCCCCCCC 4.87%HC0719483679in vivo