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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dihydropyrimidinase-related protein 2

UniprotKB/SwissProt ID: DPYL2_MOUSE (O08553)

Gene Name: Dpysl2

Synonyms: Crmp2, Ulip2

Organism: Mus musculus (Mouse).

Function: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol (By similarity). Cytoplasm, cytoskeleton (By similarity). Membrane (By similarity). Note=Tightly but non-covalently associated with membranes (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map04360Axon guidance
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR005847
IPR006680
IPR011059
IPR011778

The S-nitrosylation sites of DPYL2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1248RSITIANQTN C PLYVTKVMSK HHHHHHHHCC C CEEEEECCCH 2.52%MC0222588120-
2248RSITIANQTN C PLYVTKVMSK HHHHHHHHCC C CEEEEECCCH 2.52%MC0224895380-
3248RSITIANQTN C PLYVTKVMSK HHHHHHHHCC C CEEEEECCCH 2.52%MC0219101475-
4248RSITIANQTN C PLYVTKVMSK HHHHHHHHCC C CEEEEECCCH 2.52%MC0221278135in vitro
5248RSITIANQTN C PLYVTKVMSK HHHHHHHHCC C CEEEEECCCH 2.52%MC0222865876in vivo
6439LEYNIFEGME C RGSPLVVISQ CCCCCCCCEE E EEEEEEEEEC 4.42%MC1324895380-
7439LEYNIFEGME C RGSPLVVISQ CCCCCCCCEE E EEEEEEEEEC 4.42%MC1321278135in vitro
8439LEYNIFEGME C RGSPLVVISQ CCCCCCCCEE E EEEEEEEEEC 4.42%MC1322865876in vivo
9504VPRGLYDGPV C EVSVTPKTVT CCCCCCCCCC C CCCCCCCCCC 4.87%MC0522588120-
10504VPRGLYDGPV C EVSVTPKTVT CCCCCCCCCC C CCCCCCCCCC 4.87%MC0524895380-
11504VPRGLYDGPV C EVSVTPKTVT CCCCCCCCCC C CCCCCCCCCC 4.87%MC0519101475-