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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dihydropyrimidinase-related protein 2

UniprotKB/SwissProt ID: DPYL2_RAT (P47942)

Gene Name: Dpysl2

Organism: Rattus norvegicus (Rat).

Function: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol (By similarity). Cytoplasm, cytoskeleton (By similarity). Membrane (By similarity). Note=Tightly but noncovalently associated with membranes.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04360Axon guidance
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR005847
IPR006680
IPR011059
IPR011778

The S-nitrosylation sites of DPYL2_RAT

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1248RSITIANQTN C PLYVTKVMSK HHHHHHHHCC C CEEEEECCCH 2.52%RC0322178444-
2248RSITIANQTN C PLYVTKVMSK HHHHHHHHCC C CEEEEECCCH 2.52%RC0317629318in vitro
3504VPRGLYDGPV C EVSVTPKTVT CCCCCCCCCC C CCCCCCCCCC 4.87%RC0422178444-
4504VPRGLYDGPV C EVSVTPKTVT CCCCCCCCCC C CCCCCCCCCC 4.87%RC0416418269in vitro
5504VPRGLYDGPV C EVSVTPKTVT CCCCCCCCCC C CCCCCCCCCC 4.87%RC0417629318in vitro