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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Desmoglein-1

UniprotKB/SwissProt ID: DSG1_HUMAN (Q02413)

Gene Name: DSG1

Synonyms: CDHF4

Organism: Homo sapiens (Human).

Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, desmosome.

Protein disease:
Disease database Database Entry Disease information
KEGGH00717 Striate palmoplantar keratoderma
OMIM125670DESMOGLEIN 1; DSG1
OMIM148700KERATOSIS PALMOPLANTARIS STRIATA I; PPKS1 ;;STRIATE PALMOPLANTAR KERATODERMA I; SPPK1;; KERA
HPRD00515Keratosis palmoplantaris striata I
Network with metabolic pathway:
Kegg map ID Pathway Link
map05150Staphylococcus aureus infection
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000233
IPR002126
IPR006162
IPR009122
IPR009123
IPR015487
IPR015919

The S-nitrosylation sites of DSG1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
177RNPIAKIHSD C AANQQVTYRI CEEEEEECCC C CCCCEEEEEE 4.28%HC0424105792-