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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dynein light chain 2, cytoplasmic

UniprotKB/SwissProt ID: DYL2_MOUSE (Q9D0M5)

Gene Name: Dynll2

Synonyms: Dlc2

Organism: Mus musculus (Mouse).

Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04962Vasopressin-regulated water reabsorption
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001372

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1RE6 NMR - A/B1-89Link

The S-nitrosylation sites of DYL2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
124SEDMQQDAVD C ATQAMEKYNI CCHHHHHHHH H HHHHHHHHCC 3.38%MC0521278135in vitro
224SEDMQQDAVD C ATQAMEKYNI CCHHHHHHHH H HHHHHHHHCC 3.38%MC0522865876in vivo
356FDKKYNPTWH C IVGRNFGSYV HHHHHCCEEE E EEECCCCCEE 1.71%MC0121278135in vitro