Protein Name: Dynamin-2
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UniprotKB/SwissProt ID: DYN2_HUMAN (P50570)
Gene Name: DNM2
Synonyms: DYN2
Organism: Homo sapiens (Human).
Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Midbody. Note=Microtubule- associated. Also found in the postsynaptic density of neuronal cells.
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | KEGG | H00264 | Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atroph | | KEGG | H00700 | Centronuclear myopathy | | OMIM | 160150 | MYOPATHY, CENTRONUCLEAR, AUTOSOMAL DOMINANT ;;MYOTUBULAR MYOPATHY, AUTOSOMAL DOMINANT | | OMIM | 602378 | DYNAMIN 2; DNM2 ;;DYN2 | | OMIM | 606482 | CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B; CMTDIB ;;CHARCOT-MARIE-TOOTH NEUROPATH | | OMIM | 615368 | LETHAL CONGENITAL CONTRACTURE SYNDROME 5; LCCS5 | | HPRD | 03852 | Charcot-Marie-tooth disease, dominant intermediate B | | HPRD | 03852 | Charcot-Marie-tooth disease, dominant intermediate B, with neutropenia | | HPRD | 03852 | Myopathy, centronuclear, autosomal dominant |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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