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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Excitatory amino acid transporter 1

UniprotKB/SwissProt ID: EAA1_RAT (P24942)

Gene Name: Slc1a3

Synonyms: Eaat1

Organism: Rattus norvegicus (Rat).

Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Multi-pass membrane protein.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04724Glutamatergic synapse
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001991

The S-nitrosylation sites of EAA1_RAT

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1186NMFPPNLVEA C FKQFKTSYEK CCCCCCHHHH H HHHHHHHCCC 2.50%RC0122178444-
2186NMFPPNLVEA C FKQFKTSYEK CCCCCCHHHH H HHHHHHHCCC 2.50%RC0116418269in vitro