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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Elongation factor 1-alpha 1

UniprotKB/SwissProt ID: EF1A1_HUMAN (P68104)

Gene Name: EEF1A1

Synonyms: EEF1A, EF1A, LENG7

Organism: Homo sapiens (Human).

Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map05134Legionellosis
map03013RNA transport
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000795
IPR004160
IPR004161
IPR004539
IPR009000
IPR009001

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1SYW Model - A2-443Link

The S-nitrosylation sites of EF1A1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1111NMITGTSQAD C AVLIVAAGVG HHHHHHHHHC E EEEEEECCCC 2.94%HC1222178444-
2234SGTTLLEALD C ILPPTRPTDK CCHHHHHHHH H CCCCCCCCCC 3.42%HC1222178444-
3234SGTTLLEALD C ILPPTRPTDK CCHHHHHHHH H CCCCCCCCCC 3.42%HC1216648260in vivo
4411IVDMVPGKPM C VESFSDYPPL EEEEEECCCE E ECCCCCCCCC 4.10%HC0422178444-
5411IVDMVPGKPM C VESFSDYPPL EEEEEECCCE E ECCCCCCCCC 4.10%HC0419101475-
6411IVDMVPGKPM C VESFSDYPPL EEEEEECCCE E ECCCCCCCCC 4.10%HC0419483679in vivo