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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Elongation factor 1-delta

UniprotKB/SwissProt ID: EF1D_MOUSE (P57776)

Gene Name: Eef1d

Organism: Mus musculus (Mouse).

Function: Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome (By similarity). Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE) (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Isoform 2: Nucleus (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map05168Herpes simplex infection
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001326
IPR014038
IPR014717

The S-nitrosylation sites of EF1D_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1217DETDMAQLET C VRSIQLDGLV CCCCHHHHHH H HHHHCCCCEE 1.42%MC0622178444-
2217DETDMAQLET C VRSIQLDGLV CCCCHHHHHH H HHHHCCCCEE 1.42%MC0619483679in vivo
3217DETDMAQLET C VRSIQLDGLV CCCCHHHHHH H HHHHCCCCEE 1.42%MC0621278135in vitro