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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Translation initiation factor eIF-2B subunit epsilon

UniprotKB/SwissProt ID: EI2BE_HUMAN (Q13144)

Gene Name: EIF2B5

Synonyms: EIF2BE

Organism: Homo sapiens (Human).

Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD04898Leukoencephalopathy with vanishing white matter
HPRD04898Ovarioleukodystrophy
Network with metabolic pathway:
Kegg map ID Pathway Link
map03013RNA transport
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001451
IPR003307
IPR011004

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3JUI X-ray 2.00 A A547-721Link

The S-nitrosylation sites of EI2BE_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1618MDSPLDSSRY C ALLLPLLKAW CCCCCCCHHH H HHHHHHHHHH 1.77%HC0319483679in vivo