Protein Name: Eukaryotic translation initiation factor 3 subunit A
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UniprotKB/SwissProt ID: EIF3A_HUMAN (Q14152)
Gene Name: EIF3A
Synonyms: EIF3S10, KIAA0139
Organism: Homo sapiens (Human).
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm.
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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