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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Eukaryotic peptide chain release factor subunit 1

UniprotKB/SwissProt ID: ERF1_HUMAN (P62495)

Gene Name: ETF1

Synonyms: ERF1, RF1, SUP45L1

Organism: Homo sapiens (Human).

Function: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map03015mRNA surveillance pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR004038
IPR004403
IPR005140
IPR005141
IPR005142

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1DT9 X-ray 2.70 A A1-437Link
2HST NMR - A140-275Link
2KTU NMR - A276-437Link
2KTV NMR - A276-437Link
2LGT NMR - A1-142Link
2LLX NMR - A1-142Link
3E1Y X-ray 3.80 A A/B/C/D1-437Link
3J5Y EM 9.70 A A7-420Link

The S-nitrosylation sites of ERF1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1335NLDIMRYVLH C QGTEEEKILY CCCEEEEEEE C CCCCCEEEEE 3.31%HC0219483679in vivo