logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Fatty acid synthase

UniprotKB/SwissProt ID: FAS_HUMAN (P49327)

Gene Name: FASN

Synonyms: FAS

Organism: Homo sapiens (Human).

Function: Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00061Fatty acid biosynthesis
map04910Insulin signaling pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000794
IPR001031
IPR001227
IPR002198
IPR006162
IPR006163
IPR009081
IPR011032
IPR013149
IPR013217
IPR014030
IPR014031
IPR014043

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1XKT X-ray 2.60 A A/B2218-2502Link
2CG5 X-ray 2.70 A B2119-2207Link
2JFD X-ray 2.81 A A/B/C/D422-823Link
2JFK X-ray 2.40 A A/B/C/D422-831Link
2PX6 X-ray 2.30 A A/B2200-2511Link
3HHD X-ray 2.15 A A/B/C/D2-963Link
3TJM X-ray 1.48 A A2218-2500Link

The S-nitrosylation sites of FAS_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1212RLGMLSPEGT C KAFDTAGNGY HCCCCCCCCC C CCCCCCCCEE 4.38%HC122212679in vitro
2634GLSWEECKQR C PPGVVPACHN CCCHHHHHHH C CCCEEEEEEE 4.40%HC0219483679in vivo
3642QRCPPGVVPA C HNSKDTVTIS HHCCCCEEEE E EECCCCEEEE 2.27%HC1219483679in vivo
41118EQQVPILEKF C FTPHTEEGCL HHHCHHHHHH E ECCCCCHHHH 5.71%HC0319483679in vivo
51127FCFTPHTEEG C LSERAALQEE HEECCCCCHH H HHHHHHHHHH 4.23%HC0719483679in vivo
61471RREPGGNRLR C VLLSNLSSTS HCCCCCCEEE E EEEECCCCCC 2.75%HC0222178444-
71471RREPGGNRLR C VLLSNLSSTS HCCCCCCEEE E EEEECCCCCC 2.75%HC0218335467-
81471RREPGGNRLR C VLLSNLSSTS HCCCCCCEEE E EEEECCCCCC 2.75%HC0219366988-
92202SKADEASELA C PTPKEDGLAQ HHCCCCCCCC C CCCCCCCCCC 6.36%HC122212679in vitro