UniprotKB/SwissProt ID: FBLI1_MOUSE (Q71FD7)
Gene Name: Fblim1
Synonyms: Cal
Organism: Mus musculus (Mouse).
Function: Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell junction, focal adhesion (By similarity). Note=Associated with actin stress fiber at cell-ECM focal adhesion sites (By similarity).
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