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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Fibrillin-2

UniprotKB/SwissProt ID: FBN2_MOUSE (Q61555)

Gene Name: Fbn2

Synonyms: Fbn-2

Organism: Mus musculus (Mouse).

Function: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted, extracellular space, extracellular matrix.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000152
IPR000742
IPR001438
IPR001881
IPR002212
IPR006209
IPR006210
IPR007087
IPR008985
IPR009030
IPR011398
IPR013032
IPR013091

The S-nitrosylation sites of FBN2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1765ITVDGRDINE C ALDPDICANG CCCCCCCCCC C CCCCCCCCCC 3.84%MC1322865876in vivo
2777LDPDICANGI C ENLRGSYRCN CCCCCCCCCE E EECCCCEEEE 2.77%MC0722865876in vivo