UniprotKB/SwissProt ID: FBX2_MOUSE (Q80UW2)
Gene Name: Fbxo2
Synonyms: Fbs1, Fbx2
Organism: Mus musculus (Mouse).
Function: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Microsome membrane; Peripheral membrane protein; Cytoplasmic side.
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