dbSNO 2.0

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Protein Name: Squalene synthase

UniprotKB/SwissProt ID: FDFT_HUMAN (P37268)

Gene Name: FDFT1

Organism: Homo sapiens (Human).

Function:

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.

PDB :
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Protein disease:

Disease database	Database Entry	Disease information
OMIM	184420	FARNESYLDIPHOSPHATE FARNESYLTRANSFERASE 1; FDFT1 ;;SQUALENE SYNTHASE

Graphical Visualization of S-nitrosylation Sites:

Overview of Protein S-nitrosylation Sites with Functional and Structural Information

InterPro ID	Domain
IPR002060
IPR006449
IPR008949

3D Structure Databases:


3D structure databases
Entry	Method	Resolution (A)	Chain	Positions	View
1EZF	X-ray	2.15 A	A/B/C	35-370	Link
3ASX	X-ray	2.00 A	A	31-370	Link
3LEE	X-ray	3.20 A	A/B/C/D/E/F	31-370	Link
3Q2Z	X-ray	2.00 A	A	31-370	Link
3Q30	X-ray	2.00 A	A	31-370	Link
3V66	X-ray	1.80 A	A	31-370	Link
3VJ8	X-ray	1.52 A	A	31-370	Link
3VJ9	X-ray	1.52 A	A	31-370	Link
3VJA	X-ray	1.76 A	A/B	31-370	Link
3VJB	X-ray	2.05 A	A/B/C/D/E/F	31-370	Link
3VJC	X-ray	1.89 A	A/B/C/D/E/F	31-370	Link
3WEF	X-ray	2.35 A	A/B/C/D/E/F	31-370	Link
3WEG	X-ray	1.75 A	A	31-370	Link
3WEH	X-ray	1.87 A	A	31-370	Link
3WEI	X-ray	1.79 A	A	31-370	Link
3WEJ	X-ray	2.00 A	A	31-370	Link
3WEK	X-ray	1.85 A	A	31-370	Link

The S-nitrosylation sites of FDFT_HUMAN

No.	Position	S-nitrosylated Peptide	Secondary Structure of S-nitrosylated Peptide	Solvent Accessibility of nitrosylated Site	Substrate Motifs	PubMed ID	Experiment
1	6	-----MEFVK C LGHPEEFYNL	-----CHHHH H HCCCHHHHHH	4.65%	HC02	19483679	in vivo

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