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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Four and a half LIM domains protein 2

UniprotKB/SwissProt ID: FHL2_MOUSE (O70433)

Gene Name: Fhl2

Organism: Mus musculus (Mouse).

Function: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Nucleus (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map04380Osteoclast differentiation
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001781

The S-nitrosylation sites of FHL2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
171WHEGCFHCSR C GSSLVDKPFA CCCCCEEECC C CCCCCCCCEE 3.40%MC0521278135in vitro
271WHEGCFHCSR C GSSLVDKPFA CCCCCEEECC C CCCCCCCCEE 3.40%MC0522865876in vivo
3132WHETCFTCQR C QQPIGTKSFI CCCCCEECCC C CCCCCCCCCE 1.49%MC0521278135in vitro
4132WHETCFTCQR C QQPIGTKSFI CCCCCEECCC C CCCCCCCCCE 1.49%MC0522865876in vivo
5221TCFCDLYAKK C AGCTNPISGL CCCCCCCCCC C CCCCCCCCCC 3.76%MC0922865876in vivo
6224CDLYAKKCAG C TNPISGLGGT CCCCCCCCCC C CCCCCCCCCE 1.44%MC1022865876in vivo
7254WHNDCFNCKK C SLSLVGRGFL CCCCCCCCCC C CCCCCCCCCE 2.79%MC0521278135in vitro
8254WHNDCFNCKK C SLSLVGRGFL CCCCCCCCCC C CCCCCCCCCE 2.79%MC0522865876in vivo