UniprotKB/SwissProt ID: FKBP8_HUMAN (Q14318)
Gene Name: FKBP8
Synonyms: FKBP38
Organism: Homo sapiens (Human).
Function: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Isoform 1: Mitochondrion membrane; Single- pass membrane protein; Cytoplasmic side. Isoform 3: Mitochondrion membrane; Single- pass membrane protein; Cytoplasmic side.
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PDB :
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