UniprotKB/SwissProt ID: FKBP8_MOUSE (O35465)
Gene Name: Fkbp8
Synonyms: Fkbp38, Sam11
Organism: Mus musculus (Mouse).
Function: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side.
| |
|
