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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Filamin-A

UniprotKB/SwissProt ID: FLNA_HUMAN (P21333)

Gene Name: FLNA

Synonyms: FLN, FLN1

Organism: Homo sapiens (Human).

Function: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD02060Frontometaphyseal dysplasia
HPRD02060Frontometaphyseal dysplasia/otopalatodigital syndrome type 1
HPRD02060Heterotopia, periventricular
HPRD02060Heterotopia, periventricular, Ehlers-Danlos variant
HPRD02060Heterotopia, periventricular, with frontometaphyseal dysplasia
HPRD02060Heterotopia, periventricular/cerebrofrontofacial syndrome
HPRD02060Intestinal pseudoobstruction, neuronal, chronic idiopathic, X-linked
HPRD02060Melnick-needles syndrome
HPRD02060Otopalatodigital syndrome, type I
HPRD02060Otopalatodigital syndrome, type II
Network with metabolic pathway:
Kegg map ID Pathway Link
map04010MAPK signaling pathway
map04510Focal adhesion
map05132Salmonella infection
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001298
IPR001589
IPR001715
IPR013783
IPR014756

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2AAV NMR - A1863-1955Link
2BP3 X-ray 2.32 A A/B1863-1956Link
2BRQ X-ray 2.10 A A/B2236-2329Link
2J3S X-ray 2.50 A A/B2045-2329Link
2JF1 X-ray 2.20 A A2236-2329Link
2K3T NMR - A2427-2522Link
2K7P NMR - A1772-1956Link
2K7Q NMR - A1954-2141Link
2W0P X-ray 1.90 A A/B2236-2329Link
2WFN X-ray 3.20 A A/B1-278Link
3CNK X-ray 1.65 A A/B2559-2647Link
3HOC X-ray 2.30 A A/B2-269Link
3HOP X-ray 2.30 A A/B2-269Link
3HOR X-ray 2.70 A A/B2-269Link
3ISW X-ray 2.80 A A/B2236-2329Link
3RGH X-ray 2.44 A A/B1158-1252Link
4M9P X-ray 1.72 A A478-766Link

The S-nitrosylation sites of FLNA_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1444LEARGDSTYR C SYQPTMEGVH EEECCCCEEE E EEEECCCCCE 2.90%HC0120140087in vivo
2478SPYTVTVGQA C NPSACRAVGR CCEEEEECCC C CCCCCCEEEE 6.22%HC072212679in vitro
3478SPYTVTVGQA C NPSACRAVGR CCEEEEECCC C CCCCCCEEEE 6.22%HC0722126794in vivo
4483TVGQACNPSA C RAVGRGLQPK EECCCCCCCC C CEEEECCCHH 3.17%HC122212679in vitro
5483TVGQACNPSA C RAVGRGLQPK EECCCCCCCC C CEEEECCCHH 3.17%HC1222126794in vivo
6717LRVQVQDNEG C PVEALVKDNG EEEEEECCCC C EEEEEEEECC 2.52%HC102212679in vitro
7717LRVQVQDNEG C PVEALVKDNG EEEEEECCCC C EEEEEEEECC 2.52%HC1025040305in vivo
8717LRVQVQDNEG C PVEALVKDNG EEEEEECCCC C EEEEEEEECC 2.52%HC1018335467-
9717LRVQVQDNEG C PVEALVKDNG EEEEEECCCC C EEEEEEEECC 2.52%HC1019366988-
10733VKDNGNGTYS C SYVPRKPVKH EEECCCCEEE E EEEEECCCCE 2.10%HC082212679in vitro
11810GQGDVSIGIK C APGVVGPAEA CCCCCCCCCE E EEEEECCCCC 5.37%HC0220140087in vivo
121260EPAVDTSGVQ C YGPGIEGQGV ECCHHHCCEE E EECCCCCCEE 3.84%HC1225040305in vivo
131260EPAVDTSGVQ C YGPGIEGQGV ECCHHHCCEE E EECCCCCCEE 3.84%HC1220140087in vivo
141453HDVTDASKVK C SGPGLSPGMV EECCCCCEEE E ECCCCCEEEE 6.78%HC022212679
(Cys1165)
in vitro
152199EIVEGENHTY C IRFVPAEMGT EEEECCCCEE E EEEECCCCCE 1.57%HC042212679in vitro
162199EIVEGENHTY C IRFVPAEMGT EEEECCCCEE E EEEECCCCCE 1.57%HC0425040305in vivo
172476IDGPSKVKMD C QECPEGYRVT EECCCCCEEE E EECCCCCEEE 3.08%HC042212679in vitro
182476IDGPSKVKMD C QECPEGYRVT EECCCCCEEE E EECCCCCEEE 3.08%HC0422126794in vivo
192479PSKVKMDCQE C PEGYRVTYTP CCCCEEEEEE C CCCCEEEEEE 1.21%HC072212679in vitro
202543VFVDSLTKAT C APQHGAPGPG EEEEECCEEE E CCCCCCCCCC 6.59%HC042212679in vitro
212543VFVDSLTKAT C APQHGAPGPG EEEEECCEEE E CCCCCCCCCC 6.59%HC0425040305in vivo
222543VFVDSLTKAT C APQHGAPGPG EEEEECCEEE E CCCCCCCCCC 6.59%HC0420140087in vivo
232601LVGVHGPRTP C EEILVKHVGS EEEECCCCCC C CEEEEEECCC 7.87%HC042212679in vitro