Protein Name: Filamin-A
|
UniprotKB/SwissProt ID: FLNA_HUMAN (P21333)
Gene Name: FLNA
Synonyms: FLN, FLN1
Organism: Homo sapiens (Human).
Function: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
| PDB : ( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. ) |
|
Protein disease:
|
Disease database |
Database Entry |
Disease information | HPRD | 02060 | Frontometaphyseal dysplasia | HPRD | 02060 | Frontometaphyseal dysplasia/otopalatodigital syndrome type 1 | HPRD | 02060 | Heterotopia, periventricular | HPRD | 02060 | Heterotopia, periventricular, Ehlers-Danlos variant | HPRD | 02060 | Heterotopia, periventricular, with frontometaphyseal dysplasia | HPRD | 02060 | Heterotopia, periventricular/cerebrofrontofacial syndrome | HPRD | 02060 | Intestinal pseudoobstruction, neuronal, chronic idiopathic, X-linked | HPRD | 02060 | Melnick-needles syndrome | HPRD | 02060 | Otopalatodigital syndrome, type I | HPRD | 02060 | Otopalatodigital syndrome, type II |
|
Network with metabolic pathway:
|
|
Graphical Visualization of S-nitrosylation Sites:
|
Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
|