Protein Name: Frizzled-6
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UniprotKB/SwissProt ID: FZD6_HUMAN (O60353)
Gene Name: FZD6
Organism: Homo sapiens (Human).
Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity).
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | KEGG | H01307 | Nonsyndromic congenital nail disorder (NDNC) | | OMIM | 603409 | FRIZZLED, DROSOPHILA, HOMOLOG OF, 6; FZD6 | | OMIM | 614157 | NAIL DISORDER, NONSYNDROMIC CONGENITAL, 10; NDNC10 |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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