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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glycine dehydrogenase (decarboxylating), mitochondrial

UniprotKB/SwissProt ID: GCSP_HUMAN (P23378)

Gene Name: GLDC

Synonyms: GCSP

Organism: Homo sapiens (Human).

Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion.

Protein disease:
Disease database Database Entry Disease information
HPRD01996Glycine encephalopathy
Network with metabolic pathway:
Kegg map ID Pathway Link
map00260"Glycine, serine and threonine metabolism"
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002173
IPR003437
IPR015421
IPR015424

The S-nitrosylation sites of GCSP_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1225KRRKFLVDPR C HPQTIAVVQT CCCEEEECCC C CCCCHHHHHH 7.17%HC0124105792-