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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glycine dehydrogenase (decarboxylating), mitochondrial

UniprotKB/SwissProt ID: GCSP_MOUSE (Q91W43)

Gene Name: Gldc

Organism: Mus musculus (Mouse).

Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00260"Glycine, serine and threonine metabolism"
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR003437
IPR003439
IPR015421
IPR015424

The S-nitrosylation sites of GCSP_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1230KRKKFFVDPR C HPQTIAVVQT CCCEEEECCC C CHHHHHHHHH 7.17%MC0122178444-
2230KRKKFFVDPR C HPQTIAVVQT CCCEEEECCC C CHHHHHHHHH 7.17%MC0120837516in vivo
3762VSHLNLHKTF C IPHGGGGPGM EEECCCCCCC C CCCCCCCCCC 5.98%MC1022178444-
4762VSHLNLHKTF C IPHGGGGPGM EEECCCCCCC C CCCCCCCCCC 5.98%MC1020837516
(Cys763)
in vivo