logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Gephyrin

UniprotKB/SwissProt ID: GEPH_MOUSE (Q8BUV3)

Gene Name: Gphn

Organism: Mus musculus (Mouse).

Function: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Cytoplasmic face of glycinergic postsynaptic membranes (By similarity

Network with metabolic pathway:
Kegg map ID Pathway Link
map04727GABAergic synapse
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001453
IPR005110
IPR005111
IPR008284

The S-nitrosylation sites of GEPH_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1284QATSRLSTAS C PTPKQIRRPD HHHHCCCCCC C CCCHHHCCCC 3.95%MC0522178444-
2284QATSRLSTAS C PTPKQIRRPD HHHHCCCCCC C CCCHHHCCCC 3.95%MC0519101475-