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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glutamine synthetase

UniprotKB/SwissProt ID: GLNA_HUMAN (P15104)

Gene Name: GLUL

Synonyms: GLNS

Organism: Homo sapiens (Human).

Function: This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Mitochondrion (By similarity).

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD00701Glutamine deficiency, congenital
Network with metabolic pathway:
Kegg map ID Pathway Link
map00250"Alanine, aspartate and glutamate metabolism"
map00330Arginine and proline metabolism
map00630Glyoxylate and dicarboxylate metabolism
map04724Glutamatergic synapse
map04727GABAergic synapse
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR008146
IPR008147
IPR014746

The S-nitrosylation sites of GLNA_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1183RDIVEAHYRA C LYAGVKIAGT HHHHHHHHHH H HHCCCCEEEE 1.90%HC0324105792-
2359FSVTEALIRT C LLNETGDEPF HHHHHHHHHH H CCCCCCCCCH 2.67%HC0324105792-