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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glutaredoxin-related protein 5, mitochondrial

UniprotKB/SwissProt ID: GLRX5_MOUSE (Q80Y14)

Gene Name: Glrx5

Organism: Mus musculus (Mouse).

Function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. May protect cells against apoptosis due to reactive oxygen species and oxidative stress.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion (By similarity).

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002109
IPR004480
IPR011767
IPR012335
IPR012336

The S-nitrosylation sites of GLRX5_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
163FLKGTPEQPQ C GFSNAVVQIL EECCCCCCCC C HHHHHHHHHH 8.27%MC1322588120-
263FLKGTPEQPQ C GFSNAVVQIL EECCCCCCCC C HHHHHHHHHH 8.27%MC1321278135in vitro
363FLKGTPEQPQ C GFSNAVVQIL EECCCCCCCC C HHHHHHHHHH 8.27%MC1322865876in vivo