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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glutaminase liver isoform, mitochondrial

UniprotKB/SwissProt ID: GLSL_HUMAN (Q9UI32)

Gene Name: GLS2

Synonyms: GA

Organism: Homo sapiens (Human).

Function: Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion.

Network with metabolic pathway:
Kegg map ID Pathway Link
map00250"Alanine, aspartate and glutamate metabolism"
map00330Arginine and proline metabolism
map00471D-Glutamine and D-glutamate metabolism
map04964Proximal tubule bicarbonate reclamation
map04724Glutamatergic synapse
map04727GABAergic synapse
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002110
IPR007043
IPR012338
IPR015868

The S-nitrosylation sites of GLSL_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1136GLLDRDLFRK C VSSNIVLLTQ HHCCHHHHHH H HCCCHHHHCC 2.90%HC0224105792-